Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3.

ABSTRACT: Immunotherapies, including immune checkpoint blockades, play a critically important role in cancer treatments. For immunotherapies, neoantigens, which are generated by somatic mutations in cancer cells, are thought to be good targets due to their tumor specificity. Because neoantigens are unique in individual cancers, it is challenging to develop personalized immunotherapy targeting neoantigens. In this study, we screened "shared neoantigens", which are specific types of neoantigens derived from mutations observed commonly in a subset of cancer patients. Using exome sequencing data in the Cancer Genome Atlas (TCGA), we predicted shared neoantigen peptides and performed in vitro screening of shared neoantigen-reactive CD8⁺ T cells using peripheral blood from healthy donors. We ex

SUBMITTER: Tate T 

PROVIDER: S-EPMC9953830 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature