Secretome of Stromal Cancer-Associated Fibroblasts (CAFs): Relevance in Cancer.

ABSTRACT: The cancer secretome reflects the assortment of proteins released by cancer cells. Investigating cell secretomes not only provides a deeper knowledge of the healthy and transformed state but also helps in the discovery of novel biomarkers. Secretomes of cancer cells have been studied in the past, however, the secretome contribution of stromal cells needs to be studied. Cancer-associated fibroblasts (CAFs) are one of the predominantly present cell populations in the tumor microenvironment (TME). CAFs play key role in functions associated with matrix deposition and remodeling, reciprocal exchange of nutrients, and molecular interactions and signaling with neighboring cells in the TME. Investigating CAFs secretomes or CAFs-secreted factors would help in identifying novel CAF-specific biomarke

SUBMITTER: Mishra D 

PROVIDER: S-EPMC9953839 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature