Retinoic Acid and POU Genes in Developing Amphioxus: A Focus on Neural Development.

ABSTRACT: POU genes are a family of evolutionarily conserved transcription factors with key functions in cell type specification and neurogenesis. In vitro experiments have indicated that the expression of some POU genes is controlled by the intercellular signaling molecule retinoic acid (RA). In this work, we aimed to characterize the roles of RA signaling in the regulation of POU genes in vivo. To do so, we studied POU genes during the development of the cephalochordate amphioxus, an animal model crucial for understanding the evolutionary origins of vertebrates. The expression patterns of amphioxus POU genes were assessed at different developmental stages by chromogenic in situ hybridization and hybridization chain reaction. Expression was further assessed in embryos subjected to pharmacological m

SUBMITTER: Bozzo M 

PROVIDER: S-EPMC9953854 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature