Extracellular Vesicles in Liquid Biopsies as Biomarkers for Solid Tumors.

ABSTRACT: Extracellular vesicles (EVs) are secreted by all living cells and are ubiquitous in every human body fluid. They are quite heterogeneous with regard to biogenesis, size, and composition, yet always reflect their parental cells with their cell-of-origin specific cargo loading. Since numerous studies have demonstrated that EV-associated proteins, nucleic acids, lipids, and metabolites can represent malignant phenotypes in cancer patients, EVs are increasingly being discussed as valuable carriers of cancer biomarkers in liquid biopsy samples. However, the lack of standardized and clinically feasible protocols for EV purification and characterization still limits the applicability of EV-based cancer biomarker analysis. This review first provides an overview of current EV isolation and characte

SUBMITTER: Irmer B 

PROVIDER: S-EPMC9953862 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature