Online Adaptive MRI-Guided Radiotherapy for Primary Tumor and Lymph Node Boosting in Rectal Cancer.

ABSTRACT: The purpose of this study was to characterize the motion and define the required treatment margins of the pathological mesorectal lymph nodes (GTV_ln) for two online adaptive MRI-guided strategies for sequential boosting. Secondly, we determine the margins required for the primary gross tumor volume (GTV_prim). Twenty-eight patients treated on a 1.5T MR-Linac were included in the study. On T2-weighted images for adaptation (MRI_adapt) before and verification after irradiation (MRI_post) of five treatment fractions per patient, the GTV_ln and GTV_prim were delineated. With online adaptive MRI-guided radiotherapy, daily plan adaptation can be performed through the use of two different strategies. In an adapt-to-shape (ATS) workflow

SUBMITTER: Kensen CM 

PROVIDER: S-EPMC9953931 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature