Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas.

ABSTRACT: In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations. The analysis of gene expression in placental diseases (Pre-eclampsia and Intra-Uterine Growth Restriction) is hindered by the fact that diseased placental tissue samples are generally taken at earlier gestations compared to control samples. The difference in gestational age is considered a major confounding factor in the transcriptome regulation of the placenta. To alleviate this significant problem, we propose here a novel approach to pinpoint disease-specific cis-eQTLs. By statistical correction for gestational age at sampling as well as other confounding/surrogate variables systematically searched and iden

SUBMITTER: Apicella C 

PROVIDER: S-EPMC9954093 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature