In Silico Identification and Functional Characterization of Genetic Variations across DLBCL Cell Lines.

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma and frequently develops through the accumulation of several genetic variations. With the advancement in high-throughput techniques, in addition to mutations and copy number variations, structural variations have gained importance for their role in genome instability leading to tumorigenesis. In this study, in order to understand the genetics of DLBCL pathogenesis, we carried out a whole-genome mutation profile analysis of eleven human cell lines from germinal-center B-cell-like (GCB-7) and activated B-cell-like (ABC-4) subtypes of DLBCL. Analysis of genetic variations including small sequence variants and large structural variations across the cell lines revealed distinct variation profiles indicating the

SUBMITTER: Dharanipragada P 

PROVIDER: S-EPMC9954129 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature