Correlations between [⁶⁸Ga]Ga-DOTA-TOC Uptake and Absorbed Dose from [¹⁷⁷Lu]Lu-DOTA-TATE.

ABSTRACT:

Purpose

The aim of this paper was to investigate correlations between pre- therapeutic [⁶⁸Ga]Ga-DOTA-TOC uptake and absorbed dose to tumours from therapy with [¹⁷⁷Lu]Lu-DOTA-TATE.

Methods

This retrospective study included 301 tumours from 54 GEP-NET patients. The tumours were segmented on pre-therapeutic [⁶⁸Ga]Ga-DOTA-TOC PET/CT, and post-therapy [¹⁷⁷Lu]Lu-DOTA-TATE SPECT/CT images, using a fixed 40% threshold. The SPECT/CT images were used for absorbed dose calculations by assuming a linear build-up from time zero to day one, and mono-exponential wash-out after that. Both SUV_mean and SUV_max were measured from the PET images. A linear absorbed-dose prediction model was formed with SUV_mean as the ind

SUBMITTER: Bruvoll R 

PROVIDER: S-EPMC9954147 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature