Visual/Photoelectrochemical Off-On Sensor Based on Cu/Mn Double-Doped CeO₂ and Branched Sheet Embedded Cu₂O/CuO Nanocubes.

ABSTRACT: An integrated dual-signal bioassay was devised to fulfil thrombin (TB) ultrasensitive detection by integrating visualization with the photoelectrochemical technique based on G-quadruplex/hemin. During the process, branched sheet embedded copper-based oxides prepared with illumination and alkaline condition play a vital role in obtaining the desirable photocurrent. The switchover of photoelectrochemical signal was realized by the adjustable distance between electron acceptor G-quadruplex/hemin and interface materials due to dissociation of the Cu/Mn double-doped cerium dioxide (CuMn@CeO₂)/DNA caused by the addition of TB. Then, CuMn@CeO₂ transferred onto visual zones triggered catalytic reactions under the existence of 3,3',5,5'-tetramethylbenzidine and hydrogen peroxi

SUBMITTER: Shi H 

PROVIDER: S-EPMC9954256 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature