Enabling Cyclization Strategies through Carbonyl-Ylide-Mediated Synthesis of Malonate Enol Ethers.

ABSTRACT: Malonate enol ethers are afforded in one step by condensation of cyclic ketones with α-diazomalonates under [CpRu(CH₃CN)₃][BAr_F] catalysis. The dual reactivity of these 2-vinyloxymalonates can be used to expand the classical range of cyclizations derived from carbonyl ylide intermediates.

SUBMITTER: Vinas-Lobez J 

PROVIDER: S-EPMC9954264 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature