Antiapoptotic Gene Genotype and Allele Variations and the Risk of Lymphoma.

ABSTRACT:

Background

The findings of earlier investigations of antiapoptotic gene genotypes and allele variants on lymphoma risk are ambiguous. This study aimed to examine the relationship between the mutation in the antiapoptotic genes and lymphoma risk among Saudi patients.

Methods

This case-control study included 205 patients, 100 of whom had lymphoma (cases) and 105 who were healthy volunteers (controls). We used tetra amplification refractory mutation polymerase chain reaction (PCR) to identify antiapoptotic genes such as B-cell lymphoma-2 (BCL2-938 C > A), MCL1-rs9803935 T > G, and survivin (BIRC5-rs17882312 G > C and BIRC5-rs9904341 G > C). Allelic-specific PCR was used to identify alleles such as BIRC5-C, MCL1-G, and BIRC5-G.

Results

The domi

SUBMITTER: Al-Amer OM 

PROVIDER: S-EPMC9954290 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature