A Systematic Review on the Potential Acceleration of Neurocognitive Aging in Older Cancer Survivors.

ABSTRACT: As survival rates increase, more emphasis has gone to possible cognitive sequelae in older cancer patients, which could be explained by accelerated brain aging. In this review, we provide a complete overview of studies investigating neuroimaging, neurocognitive, and neurodegenerative disorders in older cancer survivors (>65 years), based on three databases (Pubmed, Web of Science and Medline). Ninety-six studies were included. Evidence was found for functional and structural brain changes (frontal regions, basal ganglia, gray and white matter), compared to healthy controls. Cognitive decline was mainly found in memory functioning. Anti-hormonal treatments were repeatedly associated with cognitive decline (tamoxifen) and sometimes with an increased risk of Alzheimer's disease (androgen depr

SUBMITTER: Kerstens C 

PROVIDER: S-EPMC9954467 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature