Ontology highlight
ABSTRACT:
SUBMITTER: Hilbrig C
PROVIDER: S-EPMC9954539 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Hilbrig Colmar C Löffler Jessica J Fischer Gabriel G Scheidhauer Ellen E Solbach Christoph C Huber-Lang Markus M Beer Ambros J AJ Rasche Volker V Winter Gordon G
Cancers 20230209 4
Mouse models are commonly used to study the biodistribution of novel radioligands, but alternative models corresponding to the 3Rs principles, such as the chorioallantoic membrane (CAM) model, are highly required. While there are promising data from the CAM model regarding target-specific radiolabeled compounds, its utility for assessing macromolecule biodistribution and analyzing the EPR effect remains to demonstrated. Using <sup>89</sup>Zr-labeled human serum albumin, the accumulation of nonta ...[more]