Impact of Whole Genome Doubling on Detection of Circulating Tumor DNA in Colorectal Cancer.

ABSTRACT:

Objective

Circulating tumor DNA (ctDNA) is a candidate biomarker of cancer with practice-changing potential in the detection of both early and residual disease. Disease stage and tumor size affect the probability of ctDNA detection, whereas little is known about the influence of other tumor characteristics on ctDNA detection. This study investigates the impact of tumor cell whole-genome doubling (WGD) on the detection of ctDNA in plasma collected preoperatively from newly diagnosed colorectal cancer (CRC) patients.

Methods

WGD was estimated from copy numbers derived from whole-exome sequencing (WES) data of matched tumor and normal DNA from 833 Danish CRC patients. To explore if tumor WGD status impacts ctDNA detection, we applied tumor-informed ctDNA analysis to preoperativ

SUBMITTER: Kabel J 

PROVIDER: S-EPMC9954709 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature