The Role of P16, P53, KI-67 and PD-L1 Immunostaining in Primary Vaginal Cancer.

ABSTRACT:

Background

To analyze clinical, pathological and immunohistochemical correlates of survival in vaginal cancer patients.

Methods

Retrospective analysis of primary vaginal cancer patients, treated at the Department of Gynecology and Gynecological Oncology of the University Hospital Bonn between 2007 and 2021.

Results

The study cohort comprised 22 patients. The median age was 63 years (range: 32-87 years). Squamous cell histology was present in 20 patients. Five-year OS in Stage I, II, III and IV was 100%, 56.25%, 0% and 41.67%, respectively (p = 0.147). Five-year DFS was 100%, 50%, 0% and 20.83%, respectively (p = 0.223). The 5-year OS was significantly reduced in the presence of nodal metastasis (p = 0.004), lymphangiosis (p = 0.009), hemang

SUBMITTER: Egger EK 

PROVIDER: S-EPMC9954710 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature