Pathogenic Aspects and Therapeutic Avenues of Autophagy in Parkinson's Disease.

ABSTRACT: The progressive aging of the population and the fact that Parkinson's disease currently does not have any curative treatment turn out to be essential issues in the following years, where research has to play a critical role in developing therapy. Understanding this neurodegenerative disorder keeps advancing, proving the discovery of new pathogenesis-related genes through genome-wide association analysis. Furthermore, the understanding of its close link with the disruption of autophagy mechanisms in the last few years permits the elaboration of new animal models mimicking, through multiple pathways, different aspects of autophagic dysregulation, with the presence of pathological hallmarks, in brain regions affected by Parkinson's disease. The synergic advances in these fields permit the ela

SUBMITTER: Kinet R 

PROVIDER: S-EPMC9954720 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature