Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence.

ABSTRACT: The nuclear matrix protein lamin A is a multifunctional protein with roles in DNA replication and repair, gene activation, transcriptional regulation, and maintenance of higher-order chromatin structure. Phosphorylation is the main determinant of lamin A mobility in the nucleus and nuclear membrane dissolution during mitosis. However, little is known about the regulation of lamin A phosphorylation during interphase. Interestingly, C-terminal lamin A mutations trigger cellular senescence. Recently, we showed that the C-terminal region of lamin A interacts with casein kinase II (CK2). In the present study, we have expanded on our previous research to further investigate lamin A phosphorylation and elucidate the mechanisms underlying the effect of C-terminal mutations on cellular senescence.

SUBMITTER: Ao Y 

PROVIDER: S-EPMC9954792 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature