Cortisol and ACTH Measurements at Extubation From Pituitary Surgery Predicts Hypothalamic-Pituitary-Adrenal Axis Function.

ABSTRACT:

Context

Early prediction of hypothalamic-pituitary-adrenal (HPA) axis function following transsphenoidal surgery (TSS) can improve patient safety and reduce costs.

Objective

Systematic measurement of ACTH and cortisol at extubation following anesthesia to predict remission from Cushing's disease (CD) and HPA axis preservation following non-CD surgery.

Design

Retrospective analysis of clinical data between August 2015 and May 2022.

Setting

Referral center.

Patients

Consecutive patients (n = 129) undergoing TSS who had perioperative ACTH and cortisol measurements.

Interventions

ACTH and cortisol measurement at extubation. Further serial 6-hourly measurements in CD patients.

Main outcome measures

Prediction of future HPA axis status based on A

SUBMITTER: Asuzu DT 

PROVIDER: S-EPMC9954986 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature