Relevance of Volumetric Parameters Applied to [⁶⁸Ga]Ga-DOTATOC PET/CT in NET Patients Treated with PRRT.

ABSTRACT:

Background

this study aims to explore the prognostic and predictive role of volumetric parameters on [⁶⁸Ga]Ga-DOTATOC PET/CT in neuroendocrine tumors (NET) patients treated with peptide receptor radionuclide therapy (PRRT).

Methods

We retrospectively evaluated 39 NET patients (21 male, 18 female; mean age 60.7 y) within the FENET-2016 trial (CTiD:NCT04790708). PRRT was proposed with [¹⁷⁷Lu]Lu-DOTATOC alone or combined with [⁹⁰Y]Y-DOTATOC. [⁶⁸Ga]Ga-DOTATOC PET/CT was performed at baseline and 3 months after PRRT. For each PET/CT, we calculated SUVmax, SUVmean, somatostatin receptor expressing tumor volume (SRETV), and total lesion somatostatin receptor expression (TLSRE), as well as their percentage of changes (Δ), both for liver (_

SUBMITTER: Urso L 

PROVIDER: S-EPMC9955025 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature