Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney.

ABSTRACT: Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. In an effort to identify elusive regulators of nephron segmentation, our lab conducted a high-throughput drug screen using a bioactive chemical library and developing zebrafish, which are a conserved vertebrate model and particularly conducive to large-scale screening approaches. 17β-estradiol (E2), which is the dominant form of estrogen in vertebrates, was a particularly interesting hit from this screen. E2 has been extensively studied in the context of gonad development, but roles for E2 in nephron development were unknown. Here, we report that exogenous estrogen

SUBMITTER: Wesselman HM 

PROVIDER: S-EPMC9955091 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature