The Prospects of Using Structural Phase Analysis of Microcalcifications in Breast Cancer Diagnostics.

ABSTRACT: The detection of microcalcifications in the breast by mammography is of great importance for the early diagnostics of breast cancer. This study aimed to establish the basic morphological and crystal-chemical properties of microscopic calcifications and their impact on breast cancer tissue. During the retrospective study, 55 out of 469 breast cancer samples had microcalcifications. The expression of the estrogen and progesterone receptors and Her2-neu showed no significant difference from the non-calcified samples. An in-depth study of 60 tumor samples revealed a higher expression of osteopontin in the calcified breast cancer samples (p ˂ 0.01). The mineral deposits had a hydroxyapatite composition. Within the group of calcified breast cancer samples, we detected six cases of colocal

SUBMITTER: Piddubnyi A 

PROVIDER: S-EPMC9955541 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature