Low-dose erythromycin in pediatrics: Formulation and stability of 20 mg hard gelatin capsules.

ABSTRACT:

Objective

Erythromycin is a macrolide antibiotic that is also prescribed off-label in premature neonates as a prokinetic agent. There is no oral formulation with dosage and/or excipients adapted for these high-risk patients.

Methods

Clinical studies of erythromycin as a prokinetic agent were reviewed. Capsules of 20 milligrams of erythromycin were compounded with microcrystalline cellulose. Erythromycin capsules were analyzed using the chromatographic method described in the United States Pharmacopoeia which was found to be stability-indicating. The stability of 20 mg erythromycin capsules stored protected from light at room temperature was studied for one year.

Results

20 mg erythromycin capsules have a beyond use date not lower than one year.

Conclusion

20 mi

SUBMITTER: Thevin P 

PROVIDER: S-EPMC9955640 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature