Repair of complex ovine segmental mandibulectomy utilizing customized tissue engineered bony flaps.

ABSTRACT: Craniofacial defects require a treatment approach that provides both robust tissues to withstand the forces of mastication and high geometric fidelity that allows restoration of facial architecture. When the surrounding soft tissue is compromised either through lack of quantity (insufficient soft tissue to enclose a graft) or quality (insufficient vascularity or inducible cells), a vascularized construct is needed for reconstruction. Tissue engineering using customized 3D printed bioreactors enables the generation of mechanically robust, vascularized bony tissues of the desired geometry. While this approach has been shown to be effective when utilized for reconstruction of non-load bearing ovine angular defects and partial segmental defects, the two-stage approach to mandibular reconstruct

SUBMITTER: Watson E 

PROVIDER: S-EPMC9955661 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature