Association between Urinary Creatinine Excretion and Hypothyroidism in Patients with Chronic Kidney Disease.

ABSTRACT: While hypothyroidism increases serum creatinine (Cr) levels, it is uncertain whether the elevation is mediated via a decline in the glomerular filtration rate (GFR) or the reflection of enhanced Cr production from the muscles or both. In the present study, we explored an association between urinary Cr excretion rate (CER) and hypothyroidism. A total of 553 patients with chronic kidney disease were enrolled in a cross-sectional study. Multiple linear regression analysis was performed to explore the association between hypothyroidism and urinary CER. The mean urinary CER was 1.01 ± 0.38 g/day and 121 patients (22%) had hypothyroidism. The multiple linear regression analysis revealed explanatory variables with urinary CER, including age, sex, body mass index, 24 h Cr clearance (24hrCcr), and

SUBMITTER: Matsuoka-Uchiyama N 

PROVIDER: S-EPMC9955896 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature