Can use of the serum anti-PLA2R antibody negate the need for a renal biopsy in primary membranous nephropathy?

ABSTRACT:

Background

Since the emergence of the anti-PLA2R antibody (PLA2R-Ab) test, nephrology practice has not changed dramatically, with most nephrologists still relying on a kidney biopsy to diagnose membranous nephropathy. In this study, we examined the clinical accuracy of the anti-PLA2R antibody test using ELISA in routine clinical care.

Methods

We conducted a retrospective analysis of PLA2R-Ab testing in 187 consecutive patients seen at a single UK centre between 2003 and 2020. We compared the kidney biopsy findings with the PLA2R-ab antibody test. Patients' demography, urine protein creatinine ratios, serum albumin, and treatment characteristics including supportive and immunosuppressive treatment were recorded. The clinical accuracy of the test (e.g. sensitivity and specific

SUBMITTER: Ragy O 

PROVIDER: S-EPMC9955960 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature