Gene Content and Coding Diversity of the Growth Hormone Loci of Apes.

ABSTRACT: The growth hormone (GH) locus has experienced a dramatic evolution in primates, becoming multigenic and diverse in anthropoids. Despite sequence information from a vast number of primate species, it has remained unclear how the multigene family was favored. We compared the structure and composition of apes' GH loci as a prerequisite to understanding their origin and possible evolutionary role. These thorough analyses of the GH loci of the chimpanzee, gorilla, and orangutan were done by resorting to previously sequenced bacterial artificial chromosomes (BACs) harboring them, as well as to their respective genome projects data available in GenBank. The GH loci of modern man, Neanderthal, gibbon, and wild boar were retrieved from GenBank. Coding regions, regulatory

SUBMITTER: Gonzalez-Alvarez R 

PROVIDER: S-EPMC9956162 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature