KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection.

ABSTRACT:

Background

KIF6 (kinesin family member 6), a protein coded by the KIF6 gene, serves an important intracellular function to transport organelles along microtubules. In a pilot study, we found that a common KIF6 Trp719Arg variant increased the propensity of thoracic aortic aneurysms (TAA) to suffer dissection (AD). The present study aims for a definite investigation of the predictive ability of KIF6 719Arg vis à vis AD. Confirmatory findings would enhance natural history prediction in TAA.

Methods

1108 subjects (899 aneurysm and 209 dissection patients) had KIF6 719Arg variant status determined.

Results

The 719Arg variant in the KIF6 gene correlated strongly with occurrence of AD. Specifically, KIF6 719Arg positivity (homozygous

SUBMITTER: Velasco JJ 

PROVIDER: S-EPMC9956195 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature