Emerging Therapeutic Strategies for Diffuse Intrinsic Pontine Glioma: A Systematic Review.

ABSTRACT:

Background

Of all central nervous systems tumors, 10-20% are located in the brainstem; diffuse intrinsic pontine glioma (DIPG) is diagnosed in 80% of them. With over five decades of clinical trial testing, there are no established therapeutic options for DIPG. This research article aims to collate recent clinical trial data and provide a landscape for the most promising therapies that have emerged in the past five years.

Methods

PubMed/MEDLINE, Web of Science, Scopus, and Cochrane were systematically searched using the following keywords: Diffuse intrinsic pontine glioma, Pontine, Glioma, Treatment, Therapy, Therapeutics, curative, and/or Management. Both adult and pediatric patients with newly diagnosed or progressive DIPG were considered in the clinical trial setting. The

SUBMITTER: Farrukh S 

PROVIDER: S-EPMC9956230 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature