Niosomes for Topical Application of Antioxidant Molecules: Design and In Vitro Behavior.

ABSTRACT: In the present study, gels based on xanthan gum and poloxamer 407 have been developed and characterized in order to convey natural antioxidant molecules included in niosomes. Specifically, the studies were conducted to evaluate how the vesicular systems affect the release of the active ingredient and which formulation is most suitable for cutaneous application. Niosomes, composed of Span 20 or Tween 20, were produced through the direct hydration method, and therefore, borate buffer or a micellar solution of poloxamer 188 was used as the aqueous phase. The niosomes were firstly characterized in terms of morphology, dimensional and encapsulation stability. Afterwards, gels based on poloxamer 407 or xanthan gum were compared in terms of spreadability and adhesiveness. It was found to have gre

SUBMITTER: Sguizzato M 

PROVIDER: S-EPMC9956392 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature