Transcellular chaperone signaling is an intercellular stress-response distinct from the HSF-1-mediated heat shock response.

ABSTRACT: Organismal proteostasis is maintained by intercellular signaling processes including cell nonautonomous stress responses such as transcellular chaperone signaling (TCS). When TCS is activated upon tissue-specific knockdown of hsp-90 in the Caenorhabditis elegans intestine, heat-inducible hsp-70 is induced in muscle cells at the permissive temperature resulting in increased heat stress resistance and lifespan extension. However, our understanding of the molecular mechanism and signaling factors mediating transcellular activation of hsp-70 expression from one tissue to another is still in its infancy. Here, we conducted a combinatorial approach using transcriptome RNA-Seq profiling and a forward genetic mutagenesis screen to elucidate how stress signaling from the intestine to the muscle is

SUBMITTER: Miles J 

PROVIDER: S-EPMC9956597 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature