Lymphocyte deficiency alters the transcriptomes of oligodendrocytes, but not astrocytes or microglia.

ABSTRACT: Though the brain was long characterized as an immune-privileged organ, findings in recent years have shown extensive communications between the brain and peripheral immune cells. We now know that alterations in the peripheral immune system can affect the behavioral outputs of the central nervous system, but we do not know which brain cells are affected by the presence of peripheral immune cells. Glial cells including microglia, astrocytes, oligodendrocytes, and oligodendrocyte precursor cells (OPCs) are critical for the development and function of the central nervous system. In a wide range of neurological and psychiatric diseases, the glial cell state is influenced by infiltrating peripheral lymphocytes. However, it remains largely unclear whether the development of the molecular phenotyp

SUBMITTER: Krawczyk MC 

PROVIDER: S-EPMC9956607 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature