Modeling the three-dimensional connectivity of in vitro cortical ensembles coupled to Micro-Electrode Arrays.

ABSTRACT: Nowadays, in vitro three-dimensional (3D) neuronal networks are becoming a consolidated experimental model to overcome most of the intrinsic limitations of bi-dimensional (2D) assemblies. In the 3D environment, experimental evidence revealed a wider repertoire of activity patterns, characterized by a modulation of the bursting features, than the one observed in 2D cultures. However, it is not totally clear and understood what pushes the neuronal networks towards different dynamical regimes. One possible explanation could be the underlying connectivity, which could involve a larger number of neurons in a 3D rather than a 2D space and could organize following well-defined topological schemes. Driven by experimental findings, achieved by recording 3D cortical networks organized in multi-layer

SUBMITTER: Callegari F 

PROVIDER: S-EPMC9956882 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature