Gene Expression and Epigenetic Regulation in the Prefrontal Cortex of Schizophrenia.

ABSTRACT: Schizophrenia pathogenesis remains challenging to define; however, there is strong evidence that the interaction of genetic and environmental factors causes the disorder. This paper focuses on transcriptional abnormalities in the prefrontal cortex (PFC), a key anatomical structure that determines functional outcomes in schizophrenia. This review summarises genetic and epigenetic data from human studies to understand the etiological and clinical heterogeneity of schizophrenia. Gene expression studies using microarray and sequencing technologies reported the aberrant transcription of numerous genes in the PFC in patients with schizophrenia. Altered gene expression in schizophrenia is related to several biological pathways and networks (synaptic function, neurotransmission, signalling, myelin

SUBMITTER: Bilecki W 

PROVIDER: S-EPMC9957055 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature