Calcitermin-Loaded Smart Gels Activity against Candida albicans: A Preliminary In Vitro Study.

ABSTRACT: Calcitermin is an antimicrobial peptide of 15 amino acids found in human nasal fluid characterized by antifungal and antibacterial properties. Candida albicans is the most common human fungal pathogen affecting many tissues, such as vaginal mucosa. In this study a formulation suitable for calcitermin administration on vaginal mucosa was developed for the treatment of fungal infections. To favor topical application, mucosal adhesion, and permanence, gels based on poloxamer 407 and xanthan gum were designed and compared with regard to their rheological behavior, erosion, and leakage. The selected gel was loaded with calcitermin, whose release kinetic was evaluated in vitro by Franz cells. An antifungal activity assay was conducted to assess the calcitermin anticandidal potential and t

SUBMITTER: Bellotti D 

PROVIDER: S-EPMC9957098 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature