Telomere Length, a New Biomarker of Male (in)Fertility? A Systematic Review of the Literature.

ABSTRACT: Male factors are suspected in around half cases of infertility, of which up to 40% are diagnosed as idiopathic. In the context of a continuously increased resort to ART and increased decline of semen parameters, it is of greatest interest to evaluate an additional potential biomarker of sperm quality. According to PRISMA guidelines, this systematic review of the literature selected studies evaluating telomere length in sperm and/or in leukocytes as a potential male fertility biomarker. Twenty-two publications (3168 participants) were included in this review of experimental evidence. For each study, authors determined if there was a correlation between telomere length and semen parameters or fertility outcomes. Of the 13 studies concerning sperm telomere length (STL) and semen parameters, t

SUBMITTER: Fattet AJ 

PROVIDER: S-EPMC9957201 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature