Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development.

ABSTRACT: WNT molecules are the regulators of various biological functions, including body axis formation, organ development, and cell proliferation and differentiation. WNTs have been extensively studied as causative genes for an array of diseases. WNT10A and WNT10B, which are considered to be genes of the same origin, have been identified as causative genes for tooth deficiency in humans. However, the disrupted mutant of each gene does not show a decrease in teeth number. A negative feedback loop, interacting with several ligands based on a reaction-diffusion mechanism, was proposed to be important for the spatial patterning of tooth formation, and WNT ligands have been considered to play a pivotal role in controlling tooth patterning from mutant phenotypes of LDL receptor-related pr

SUBMITTER: Yoshinaga K 

PROVIDER: S-EPMC9957325 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature