Characterization and Expression of Holothurian Wnt Signaling Genes during Adult Intestinal Organogenesis.

ABSTRACT: Wnt signaling has been shown to play multiple roles in regenerative processes, one of the most widely studied of which is the regeneration of the intestinal luminal epithelia. Most studies in this area have focused on self-renewal of the luminal stem cells; however, Wnt signaling may also have more dynamic functions, such as facilitating intestinal organogenesis. To explore this possibility, we employed the sea cucumber Holothuria glaberrima that can regenerate a full intestine over the course of 21 days after evisceration. We collected RNA-seq data from various intestinal tissues and regeneration stages and used these data to define the Wnt genes present in H. glaberrima and the differential gene expression (DGE) patterns during the regenerative process. Twelve Wnt

SUBMITTER: Auger NA 

PROVIDER: S-EPMC9957329 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature