Exploring Serum Transferrin Regulation of Nonferric Metal Therapeutic Function and Toxicity.

ABSTRACT: Serum transferrin (sTf) plays a pivotal role in regulating iron biodistribution and homeostasis within the body. The molecular details of sTf Fe(III) binding blood transport, and cellular delivery through transferrin receptor-mediated endocytosis are generally well-understood. Emerging interest exists in exploring sTf complexation of nonferric metals as it facilitates the therapeutic potential and toxicity of several of them. This review explores recent X-ray structural and physiologically relevant metal speciation studies to understand how sTf partakes in the bioactivity of key non-redox active hard Lewis acidic metals. It challenges preconceived notions of sTf structure function correlations that were based exclusively on the Fe(III) model by revealing distinct coordination modalities th

SUBMITTER: Benjamin-Rivera JA 

PROVIDER: S-EPMC9957567 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature