Background per- and polyfluoroalkyl substances (PFAS) in laboratory fish diet: Implications for zebrafish toxicological studies.

ABSTRACT: Current attention is focused on determining the potential for per- and polyfluoroalkyl substances (PFAS) to adversely impact human health. Zebrafish are a popular biological model because they share early development pathways with humans. A dietary exposure paradigm is growing in popularity in the zebrafish model because the outcomes often translate to humans. To create a diet of known composition, it is crucial to understand background PFAS levels present in zebrafish diet. Background PFAS, if present, potentially confounds interpretation of toxicological data. To date, no studies document the PFAS background levels in laboratory fish diet and there is only limited information on some pet foods. The objective of this study was to develop and validate an analytical method for up to 50 targ

SUBMITTER: Cao D 

PROVIDER: S-EPMC9957603 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature