A Prognostic Cuproptosis-Related LncRNA Signature for Colon Adenocarcinoma.

ABSTRACT:

Background

Cuproptosis, a recently discovered form of cell death, is caused by copper levels exceeding homeostasis thresholds. Although Cu has a potential role in colon adenocarcinoma (COAD), its role in the development of COAD remains unclear.

Methods

In this study, 426 patients with COAD were extracted from the Cancer Genome Atlas (TCGA) database. The Pearson correlation algorithm was used to identify cuproptosis-related lncRNAs. Using the univariate Cox regression analysis, the least absolute shrinkage and selection operator (LASSO) was used to select cuproptosis-related lncRNAs associated with COAD overall survival (OS). A risk model was established based on the multivariate Cox regression analysis. A nomogram model was used to evaluate the prognostic signature based on

SUBMITTER: Zhong L 

PROVIDER: S-EPMC9957631 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature