TREM2 as a Prognostic Biomarker for Osteosarcoma Microenvironment Remodeling.

ABSTRACT: The tumor microenvironment (TME) acts as a crucial role in the occurrence and development of osteosarcoma (OS). Despite this, the mechanism controlling the components of immunity and stroma in the tumor microenvironment remains a mystery. To conduct this study, we download and collate transcriptome data from the TARGET database, whose full name is Therapeutically Applicable Research to Generate Effective Treatments, as well as available clinical information of OS. The CIBERSORT and ESTIMATE methodology are used to acquire the proportions of components of immunity and stroma and tumor-infiltrating immune cells (TICs). Protein-protein interaction (PPI) networks and Cox regression analysis are used to select differentially expressed genes (DEGs). A prognostic biomarker is determined by inters

SUBMITTER: Shen ZL 

PROVIDER: S-EPMC9957636 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature