Structural modelling of human complement FHR1 and two of its synthetic derivatives provides insight into their in-vivo functions.

ABSTRACT: Human complement is the first line of defence against invading pathogens and is involved in tissue homeostasis. Complement-targeted therapies to treat several diseases caused by a dysregulated complement are highly desirable. Despite huge efforts invested in their development, only very few are currently available, and a deeper understanding of the numerous interactions and complement regulation mechanisms is indispensable. Two important complement regulators are human Factor H (FH) and Factor H-related protein 1 (FHR1). MFHR1 and MFHR13, two promising therapeutic candidates based on these regulators, combine the dimerization and C5-regulatory domains of FHR1 with the central C3-regulatory and cell surface-recognition domains of FH. Here, we used AlphaFold2 to model the structure of these

SUBMITTER: Ruiz-Molina N 

PROVIDER: S-EPMC9957715 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature