Adiposity impacts cognitive function in Asian populations: an epidemiological and Mendelian Randomization study.

ABSTRACT:

Background

Obesity and related metabolic disturbances including diabetes, hypertension and hyperlipidemia predict future cognitive decline. Asia has a high prevalence of both obesity and metabolic disease, potentially amplifying the future burden of dementia in the region. We aimed to investigate the impact of adiposity and metabolic risk on cognitive function in Asian populations, using an epidemiological analysis and a two-sample Mendelian Randomization (MR) study.

Methods

The Health for Life in Singapore (HELIOS) Study is a population-based cohort of South-East-Asian men and women in Singapore, aged 30-84 years. We analyzed 8769 participants with metabolic and cognitive data collected between 2018 and 2021. Whole-body fat mass was quantified with Dual X-Ray Absorptiometry

SUBMITTER: Mina T 

PROVIDER: S-EPMC9957736 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature