Automated and manual segmentation of the hippocampus in human infants.

ABSTRACT: The hippocampus, critical for learning and memory, undergoes substantial changes early in life. Investigating the developmental trajectory of hippocampal structure and function requires an accurate method for segmenting this region from anatomical MRI scans. Although manual segmentation is regarded as the "gold standard" approach, it is laborious and subjective. This has fueled the pursuit of automated segmentation methods in adults. However, little is known about the reliability of these automated protocols in infants, particularly when anatomical scan quality is degraded by head motion or the use of shorter and quieter infant-friendly sequences. During a task-based fMRI protocol, we collected quiet T1-weighted anatomical scans from 42 sessions with awake infants aged 4-23 months. Two exp

SUBMITTER: Fel JT 

PROVIDER: S-EPMC9957787 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature