Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth.

ABSTRACT:

Background

In the USA, genetically admixed populations have the highest asthma prevalence and severe asthma exacerbations rates. This could be explained not only by environmental factors but also by genetic variants that exert ethnic-specific effects. However, no admixture mapping has been performed for severe asthma exacerbations.

Objective

We sought to identify genetic variants associated with severe asthma exacerbations in Hispanic/Latino subgroups by means of admixture mapping analyses and fine mapping, and to assess their transferability to other populations and potential functional roles.

Methods

We performed an admixture mapping in 1124 Puerto Rican and 625 Mexican American children with asthma. Fine-mapping of the significant peaks was performed via allelic te

SUBMITTER: Herrera-Luis E 

PROVIDER: S-EPMC9957797 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature