Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles.

ABSTRACT:

Introduction/aims

Body mass index (BMI) is linked to amyotrophic lateral sclerosis (ALS) risk and prognosis, but additional research is needed. The aim of this study was to identify whether and when historical changes in BMI occurred in ALS participants, how these longer term trajectories associated with survival, and whether metabolomic profiles provided insight into potential mechanisms.

Methods

ALS and control participants self-reported body height and weight 10 (reference) and 5 years earlier, and at study entry (diagnosis for ALS participants). Generalized estimating equations evaluated differences in BMI trajectories between cases and controls. ALS survival was evaluated by BMI trajectory group using accelerated failure time models. BMI trajectories and survival associ

SUBMITTER: Goutman SA 

PROVIDER: S-EPMC9957813 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature