Oral and intravenous iron treatment alter the gut microbiome differentially in dialysis patients.

ABSTRACT:

Objective

Chronic kidney disease (CKD) is often complicated by anemia, which seriously affects the quality-of-life and prognosis of patients. These patients usually need iron replacement therapy. Oral iron affects the composition and abundance of intestinal flora by increasing intestinal iron concentration.

Methods

We undertook an interventional study to investigate the effects of oral versus intravenous iron therapy on the gut microbiota. Oral ferrous succinate tablets (n = 14) or intravenous iron sucrose (n = 14) was administered to anemic maintenance hemodialysis (MHD) patients for 2 months.

Results

Oral and intravenous iron treatments had different effects on gut microbial composition and diversity. After oral iron treatment, the α-diversity was decreased, while a

SUBMITTER: Liu H 

PROVIDER: S-EPMC9957911 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature