Neural atrophy produced by AAV tau injections into hippocampus and anterior cortex of middle-aged mice.

ABSTRACT: Animal models of tauopathy help in understanding the role of mutations in tau pathobiology. Here, we used adeno-associated viral (AAV) vectors to administer three tau genetic variants (tau^wild-type, tau^P301L, and tau^R406W) intracranially into 12-month-old C57BL/6Nia mice and collected tissue at 16 months. Vectors designed to express green fluorescent protein controlled for surgical procedures and exogenous protein expression by AAV. The tau genetic variants produced considerably different phenotypes. Tau^wild-type and tau^P301L caused memory impairments. The tau^P301L caused increased amounts of aggregated tau, measured both neurochemically and histologically. Tau^wild-type produced elevated levels of soluble tau and

SUBMITTER: Tetlow AM 

PROVIDER: S-EPMC9957956 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature