Temporal Patterns in Brain Tissue and Systemic Oxygenation Associated with Mortality After Severe Traumatic Brain Injury in Children.

ABSTRACT:

Background

Brain tissue hypoxia is an independent risk factor for unfavorable outcomes in traumatic brain injury (TBI); however, systemic hyperoxemia encountered in the prevention and/or response to brain tissue hypoxia may also impact risk of mortality. We aimed to identify temporal patterns of partial pressure of oxygen in brain tissue (PbtO₂), partial pressure of arterial oxygen (PaO₂), and PbtO₂/PaO₂ ratio associated with mortality in children with severe TBI.

Methods

Data were extracted from the electronic medical record of a quaternary care children's hospital with a level I trauma center for patients ≤ 18 years old with severe TBI and the presence of PbtO₂ and/or intracranial pressure monitors. Temporal analyses w

SUBMITTER: Rakkar J 

PROVIDER: S-EPMC9957965 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature