Associations between residential volatile organic compound exposures and liver injury markers: The role of biological sex and race.

ABSTRACT: While occupational exposures to volatile organic compounds (VOCs) have been linked to steatohepatitis and liver cancer in industrial workers, recent findings have also positively correlated low-dose, residential VOC exposures with liver injury markers. VOC sources are numerous; factors including biological make up (sex), socio-cultural constructs (gender, race) and lifestyle (smoking) can influence both VOC exposure levels and disease outcomes. Therefore, the current study's objective is to investigate how sex and race influence associations between residential VOC exposures and liver injury markers particularly in smokers vs. nonsmokers. Subjects (n = 663) were recruited from residential neighborhoods; informed consent was obtained. Exposure biomarkers included 16 urinary VOC metabolites.

SUBMITTER: Wahlang B 

PROVIDER: S-EPMC9957966 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature